| 报告题目 | Diversity of bacterial flagellar motors: from structure to regulation |
| 报告人 | Prof. AU Shannon |
| 报告人单位 | School of Life Sciences, The Chinese University of Hong Kong |
| 报告时间 | 2016-03-07 |
| 报告地点 | 合肥微尺度物质科学国家实验室九楼会议室（9004） |
| 主办单位 | 合肥微尺度物质科学国家实验室、中国科学技术大学物理学院 |
| 报告介绍 | 报告内容简介:
The directional movement of bacteria is governed by the motor switch complex and is an important virulence factor for pathogenic bacteria colonizationand infection.Flagellar motor switch complex, also called C-ring, is a supramolecular structure typically self-assembled by multiple copies of FliG, FliM and FliN. The switch complex is essential for flagellar assembly, torque generation and bi-directional rotational switching. While the core elements of the motor aregenerally homologous, recent genomics, transcriptomic and biophysical studies suggeststructural diversity of bacterial flagellar motors. In this regards,little is known about the flagellar motor in gastric pathogenH. pylori whose genome harbors an additional switch gene encoding FliY. In this presentation, I will present our recent findings on FliY-FliN binary complex. Additionally, the structure-function relationship of a newly identified MSC interacting protein associated to the regulation of motor function will be discussed.
报告人简介:
Prof. Au received her PhD from University of Hong Kong, carried out postdoctoral research at University of Oxford, and is now an associate professor in the School of Life Sciences at The Chinese University of Hong Kong. Her research interests focus on flagellar system in H. pylori and protein post-translational modifications. Other collaborative research projects include innate immunity and muscle differentiation. |
