| 报告题目 | Multifunctional Nanocapsules for Targeted Bioimaging and Theranostic Applications |
| 报告人 | Prof. John Wang |
| 报告人单位 | National University of Singapore, Department of Materials Science and Engineering |
| 报告时间 | 2014-06-06 |
| 报告地点 | 合肥微尺度物质科学国家实验室一楼科技展厅 |
| 主办单位 | 合肥微尺度物质科学国家实验室 |
| 报告介绍 | Abstract: We have successfully developed PEOlated polymeric micelle/silica as multifunctional nanocapsules for targeted bioimaging and controlled delivery. Bioimaging contrast agents, such as fluorescent conjugated polymers, CdSe/CdS/ZnS quantum dots (QDs), and Fe3O4 nanocrystals have been successfully encapsulated into poly(ethylene oxide) (PEO)-based polymeric micelle/silica dual layers via interfacial templating condensation. The encapsulation follows a green and straightforward microemulsion mechanism that directly proceeds in a near neutral pH aqueous environment. No detriment effects to the optical and magnetic properties of fluorescent conjugated polymers, QDs and Fe3O4 nanocrystals are observed during encapsulation. The core-shell nanocapsules thus generated possess a polymeric micelle framework with a single QD/Fe3O4 nanocrystal encapsulated in the hydrophobic micellar core, an ultrathin (<5 nm in thickness) yet robust silica shell confined to the micellar core/corona interface and free PEO chains dangling on the surface. The free PEO chains effectively prevent nonspecific adsorption of biomolecules to the nanoparticles. Double shielding of polymeric micelle/silica shell remarkably improves the fluorescence resistance of conjugated polymers and QDs to strong acids and highly salted buffers. In vitro testing using MDA-MB-231 breast cancer cells demonstrates that these organic/inorganic dual layer-protected nanocapsules conjugated with folate show noncytotoxicity, bright fluorescence cellular imaging with high target specificity and improved performance in controlled delivery. |
